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As expected, statin-treated males and females both experienced reduced levels of hepatic cholesterol species (females had reduced free cholesterol, and males reduced cholesterol esters), and both showed trends to very modest reductions in mevalonate pathway intermediates (females reduced geranylgeranyl pyrophosphate, and males trended to reduced CoQ 10 and farnesyl pyrophosphate) (Suppl

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The hDP cells were pre-treated with or without 10 M endo-IWR1 or 10 M IWP2 (both from Tocris Bioscience, Bristol, UK) for 24 h before other experiments

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